기본 정보
신청서
외용 물약, 좌약, 풀, 태블릿, 캡슐
추출 소스
Huperzia Serrata (Thunb.) Trev.
Molecular Formula
C15h18n2o
제품 설명
Product Description
1) Both Natural and Synthetic huperzine-A are available
2) Free sample, MOQ 10grams
3) Ready to ship and drop shipping, In stock
4) Leading manufacturer of huperzia serrata extract
5) COA, MSDS, TDS, MOA, Flowchart, COMPOSITION BREAKDOWN, Chromatogram and other documents
6) Plant ID test,Carbon 14 test, HPLC test, 1% to 99% huperzine-A, 0.1% huperzine-B
7) OEM service, capsule and tablets available
2, Honor
Our company was founded in 2007 which is a high-tech enterprise specializing in the development, extraction, processing of active ingredients from natural plant extracts and herbal extracts, as well as the production of pharmaceutical intermediate, monomer and health care products.
The first product is Huperzia Serrata Extract Huperzine-A, and been awarded honorary for many times until now.
Our products are selling more than 100 countries.
Product Description
Huperzia serrata (TCM = Qian Ceng Ta/Jin Bu Huan) is a plant known as a firmoss which
contains the acetylcholinesterase inhibitor huperzine A. It is widely distributed over-the-counter as a nootropic and dietary supplement.
This species is native to China, India and southeast Asia.
Huperzine A is a reversible acetylcholinesterase inhibitor and NMDA receptor antagonist that crosses the blood-brain barrier. A 2013 meta analysis found that huperzine A may be efficacious in improving cognitive function, global clinical status, and activities of daily living for individuals with Alzheimer's disease.
Huperzine A is also marketed as a dietary supplement with claims made forits ability to improve memory and mental function. Huperzine A may also have a possible role in the treatment of myasthenia gravis.
Product Name | Huperzine-A |
Botanical source | Huperzia serrata (Thunb.) Trev. |
Molecular formula | C15H18N2O |
Molecular weight | 242.32 |
Specification | 1% to 99% |
Color | White or brown powder |
CAS No. | 102518-79-6 |
Method of analysis of Huperzine-A
Testing Method
Number: Hup-A 001
Content determination of Huperzine A 1%
Adopting chromatographic column ZORBAXSB-C18 (150mm×4.6mm, 5μm);
Mobile phase: 0.02mol - L-1 KH2PO4 acetonitrile (92:8);
Wavelength checking: 310nm;
Flow velocity: 1ml/min;
Column temperature: 25ºC.
Take proper amount of the product, dilute it with HCl of 0.01 mol / L to be a solution of 40 µg / ml, then measure 20µl of it accurately and pour it into liquid chromatograph. Record the chromatogram, take proper amount of control article of huperzine A and test by the same method. Calculate the peak area by external standard method. Determinate by HPLC and calculate by external standard method, the content should not be less than 1%.
COMPOSITION BREAKDOWN of huperzine-A
Product Name: | Huperzia serrata extract Huperzine-A | Content1%(HPLC) | |
ITEMS | Component content | |
Huperzine-A | | | 1% | |
Huperzia serrata glucoside | | | 4% | |
Flavone | | | 3% | |
Alkaloid | | | 2% | |
Medical Dextrine | | | 90% | |
4 Function and application
1.Treating myasthenia gravis;
2.Treating age-related memory decline and Alzheimer's disease;
3.HuperzineA can help young people with learning disabilities;
4.Memory enhancement.
Huperzine A is a powerful and reversible cholinesterase inhibitor. The effect of treating myasthenia gravis is similar to neostigmine, and the duration of the effect is significantly longer than neostigmine, with low toxicity and less adverse reactions. Huperzine A can significantly improve the cognitive function, behavior and mood disorders, activities of daily living and overall function of AD patients, with good safety. It is suitable for benign memory disorders, and improves the ability of patients to point to memory, associative learning, image recall, meaningless figure recognition and portrait recall. It can also improve the memory impairment caused by dementia patients and brain organic diseases
Pharmacological Actions
This product is an extract from huperziaserrata (Thunb) Trev (huperziaserrata) of Huperzia family, which can promote memory reproduction and enhance memory retention. Its action characteristics are similar to neostigmine, but it has the following advantages: it has selective inhibition on true cholinesterase, and the inhibition intensity is thousands of times that of pseudocholinesterase; The inhibition mode is a mixture of competitive and non competitive inhibition, which is significantly different from the simple competitive inhibitor; It is easy to enter the center through the blood-brain barrier and has central and peripheral therapeutic effects; Long effective time; Good absorption from gastrointestinal tract; High safety index; Good stability.
The potency of ache was compared among different drugs.
The results were: huperzine a > physostigmine > neostigmine > huperzine B > galanthamine > Gal; The inhibitory intensity of BuChE was: physostigmine > neostigmine > huperzine a > huperzine B. The effect of this product on strengthening the muscle contraction amplitude caused by indirect electrical stimulation of nerves and enhancing the memory function of rats is stronger than that of physostigmine, but the toxicity is lower than that of physostigmine, and the action time is long.
Pharmacokinetics
The blood concentration time curve of rats after intraperitoneal injection or oral administration was analyzed to conform to the two compartment open model, intravenous or oral administration t1/2 α 6.7min and 9.8min respectively. t1/2 β 121.6min and 247.5min respectively. 15min after intravenous injection, the contents of kidney and liver were the highest, followed by lung, spleen, adrenal gland, heart fat and brain. After 24 hours, the content in various organs is close to trace, and a small amount of drugs can enter the fetus through the placenta. After administration, this product is mainly discharged through the kidney, 73.6% of the dosage is discharged in 24h, and 2.8% ± 1.2% of the dosage is discharged from feces. The total excretion within 7 days was 86.1% of the injection volume, some of which were metabolites.
Contraindication
People with bradycardia, bronchial asthma, please in accordance with the doctor when taking huperzine-A
Clinical assessment
This verification adopts the international and domestic standardized assessment. The results show that the total effective rate of Huperzine A in improving the memory of benign memory disorders is 86.6%, of which the marked rate is 83.6%, the effective rate is 3.0%, and the total effective rate of the Naofukang group is 52.9%, of which The markedly effective rate was 41.1% and the effective rate was 11.8%; the total effective rate of Huperzine A in improving memory in the organic dementia group was 61.0%, of which the markedly effective rate was 43.8%, the effective rate was 17.2%, and the total effective rate in the Naofukang group was 46.8%. Among them, the markedly effective rate was 42.6%, and the effective rate was 4.2%; the total effective rate of Huperzine A in improving cognitive function was 53.2%, of which the markedly effective rate was 43.8%, and the effective rate was 9.4%; the total effective rate of the Naofukang group was 51.0%, of which the markedly effective rate 34.0%, the effective rate was 17.0%; the effective rate of Huperzine A in improving mood and behavioral disorders was 65.2%, and the effective rate of the Naofukang group was 36.1%.
The clinical verification results prove that huperzine A has a positive effect on the memory improvement of benign memory disorders, has a good effect on the memory improvement of brain organic memory disorders and dementia, and also has a certain effect on the improvement of emotional behavior disorders. The clinical dosage is 100-200μg/time, bid or tid, and the maximum is not more than 450 μg/d. At this dose, there is no serious toxicity and side effects, and there is no damage to the heart, liver and kidney functions.
Packaging & Shipping
1kg package:two-layer food plastic bag and Aluminum foil bag per kg;
Aluminum foil bag 1 kg/bag,
25 kg/barrel or according to customer requirements
DHL/FEDEX/UPS/EMS, by sea, by air, by rail.
Company Profile
Our company was founded in 2007 which is a high-tech enterprise specializing in the development, extraction, processing of active ingredients from natural plant extracts and herbal extracts, as well as the production of pharmaceutical intermediate, monomer and health care products.
FAQ
Q1: Are you a manufacturer or trading company?
We are manufacture,we have our own products.We supply high quality products.
Q2: Can I have free samples?
Yes.
Q3: How do I pay the sample fee?
Paypal,Western Union,T/T or Freight collect.
Q4: How do you treat quality complaint?
If quality problem caused by us after Third Party Test, we will send you free goods for replacement or refund your payment.
Q5:What's your MOQ and lead time?
Generally MOQ is 1kg, some low value products, MOQ is 25kg and lead time is within 5-7 workdays upon your payment.
Q6: Which products you can export?
We are mainly exporting herbal extracts, amino acids, vitamins, cosmetics and APIs.
Q7: Which documents you can provide?
Usually, we provide Commercial Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.
주소:
a 2006, Yikongjian Huaxia, Gaoxin 5th Road, China. (721006), Baoji, Shaanxi, China
사업 유형:
제조사/공장
사업 범위:
화학공업
경영시스템 인증:
ISO 9001
회사소개:
Baoji Runyu Bio-Technology Co., Ltd. 중국에서 15년 이상 식재료 추출물과 허브추출물, 그리고 식품 첨가제, 과일 분말 및 의료 제품에 포함된 활성 성분에 특화된 제품입니다.
당사는 높은 품질을 보장하기 위해 여러 타사 테스트 기관과 장기적인 관계를 유지하고 있습니다.
회사의 주요 제품은 Huperzia serrata Extract-Huperzine-A, Horse Chestnut Extract-Aescin, Polygonum Cuspium Extract/Grape Skin Extract-Resveratrol, Butcher′s Broom-Extract Ruscogenin, Phloretin, okra, curcine, Sinomenine Hydrochloride, 염화 Berbamine Hydrochloride, 인삼 추출물 - Ginenosside, Evoque diamdiamine, Dioscorea Nipponia Extract Diosgenin, Celangulin, Tetrahydrocurcin, Xanthin, zeaxanthin, 우르솔릭 산, 나링인 및 네오헤스페리딘 계열 제품, 루테올린, 나타토키나아제, 피페린, 페오니클로린, 페조스파티딜세린(Pjospatidyllserine) 우리 제품의 대부분은 내륙, 마카오, 대만, 유럽, 미국, 동남 아시아 및 기타 국가와 지역에 판매되고, 이러한 지역에서 높은 인기를 누리고, 국내외 식품, 의료 제품 및 화장품 생산 업체의 선호 제품이 됩니다.
"품질 우선, 고객 우선, 진실한 관리"라는 개념을 가지고, 우리는 품질 브랜드를 구축하는 데 최선을 다합니다. 우리는 전 세계의 친구들과 소통하고 협력하기를 기대하고 있습니다. 내일 멋진 일을 만들기 위해 손을 잡고 일합시다.