Mupirocin Basic information
MUPIROCIN;MUPIROCIN CALCIUM;L-talo-Non-2-enonic acid, 5,9-anhydro-2,3,4,8-tetradeoxy-8-(2S,3S)-3-(1S,2S)-2-hydroxy-1-methylpropyloxiranylmethyl-3-methyl-, 8-carboxyoctyl ester, (2E)-;MUPIROCIN,USP;Bactoderm;Bactroban Ointment;L-talo-Non-2-enonic acid, 5,9-anhydro-2,3,4,8-tetradeoxy-8-[[(2S,3S)-3-[(1S,2S)-2-hydroxy-1-methylpropyl]oxiranyl]methyl]-3-methyl-, 8-carboxyoctyl ester, (2E)- (9CI);L-talo-Non-2-enonic acid, 5,9-anhydro-2,3,4,8-tetradeoxy-8-[[3-(2-hydroxy-1-methylpropyl)oxiranyl]methyl]-3-methyl-, 8-carboxyoctyl ester, [2E,8[2S,3S(1S,2S)]]-
Mupirocin (pseudomonic acid A) is an antibiotic produced by Pseudomonas fluorescens. It is useful in the treatment of dermal infections, especially those involving S. aureus and S. epidermidis.
The crude drug of Bactroban ointment produced by the well-known domestic pharmaceutical company SmithKline is mupirocin which is a new type of local topical antibiotic and a kind of metabolic substance produced in the culture solution of pseudomonas fluorescence, that is, Pseudomonas A. Mainly through reversibly combined with isoleucine transfer RNA synthetase, this product can prevent the isoleucine incorporation and terminate the protein synthesis in cells containing isoleucine, leading to bacterial death. At low concentrations, this product has the inhibitory effect and at high concentrations, it has the bactericidal effect. This product is highly sensitive to a variety of gram-positive bacteria associated with skin infections, particularly staphylococcus aureus (including drug-resistant staphylococcus aureus) and streptococcus pyogenes; and it is also available for listeria monocytogenes and erythema erysipelothrix bacteria; it is generally not sensitive to gram-negative bacteria, but have some antibacterial effect on some Gram-negative bacteria such as E. coli, neisseria, haemophilus influenzae and Neisseria gonorrhoeae and is not sensitive to the majority of anaerobic bacteria and the normal flora of the skin and has low efficacy against fungi. Rate of occurrence is very low in vitro resistant mutants. After applied into the skin, this medicine can penetrate into the stratum corneum, but the absorption rate is very low. The binding rate of this drug and human serum protein is 95%. when absorbed, it is rapidly metabolized to an inactive substance single spore acid (Monic Acid) and excreted by the kidneys. The minimum inhibitory concentration of most sensitive staphylococcus is 0.01-0.25mg/L, that of sensitive streptococcus is 0.06-0.5mg/L, and that of listeriosis is 8mg/L. This product is more effective in vitro tests under acidic conditions than that under alkaline conditions. When human serum exists, activity of this drug reduce to 1/10-1/20.
Topical antibiotics. This product is generally used for the inflammation of the skin, eczema, etc., or made into mupirocin ointment in the market.By reversibly binding to isoleucine transfer RNA synthetase, this product can prevent isoleucine incorporated so that the synthesis of all proteins in cells containing isoleucine can be stopped.
Mupirocin has a unique mode of action. The epoxide-containing monic acid tail of the molecule is an analog of isoleucine and, as such, is a competitive inhibitor of isoleucyltRNA synthetase in bacterial cells. The corresponding mammalian enzyme is unaffected.
antibacterial, antimycoplasmal, isoleucyl-tRNA synthetase inhibitor
Mupirocin, is a major component of the pseudomonic acid, an antibiotic complex produced by Pseudomonas fluorescens NCIB 10586. Topical antibacterial.
Pseudomonic acid is a potent antibiotic produced by Pseudomonas fluorescens, reported by Fuller et al. in 1971. Pseudomonic acid has broad spectrum activity against Gram positive bacteria and was approved for topical human use in 1985. Pseudomonic acid acts as a potent and selective inhibitor of isoleucyl-tRNA synthetase.
vasodilator
An antibiotic inhibitor of isoleucyl-tRNA synthetase
| Item |
parameter |
| Name |
Mupirocin |
| Synonyms |
MUPIROCIN CALCIUM |
| CAS |
12650-69-0 |
| Molecular Formula |
C26H44O9 |
| Formula Weight |
500.62 |
| Appearance |
white to off-white powder |
| Melting Point |
77-780C |
| Boiling point |
672ºC |
| Assay |
99% |
| Water |
<0.5% |
| Residue on ignition |
<0.5% |
| Stability |
Stable |
| Storage Temp |
room temperature and avoid light |
| Origin |
Wuhan China |
| Application |
Mupirocin Base and Calcium |
| Delivery |
by land,EMS,TNT,DHL,UPS,FEDEX |
Packing
Liquid products
- 25kg,50kg,180kg,200kg,250kg,1000kg,as your needs
Solid products
Shipping
Logistics transportation methods can be divided into various ways according to the different transportation means.
• Transit could be DHL,UPS,TNT,EMS,Fedex,and so on.
• For mass orders, it will be delivered by air or sea.
• Depending on your location, please allow 1-5 business days for your order to arrive.
• For small order, please expect 3-7 days by UPS DHL EMS.
• For mass order, please allow 5-8 days by Air, 15-30 days by Sea.
Our service
- We have our own research and development team, laboratory, pilot workshop and production plant.
- Factory production has the most stable and the best production processes, to ensure that you are given the best prices and the highest quality products.
- Not only do we provide our customers with products, but we also provide them with free product usage methods and subsequent technical guidance
- The customer comes first, we provide reasonable price, high quality product and prompt shipment.
- We can send the goods to your delivery address directly. It is relatively safe and fast. We have ready goods in stock.
- Quick and clear response to customers questions.Warm after sale service, we will help to solve the problems in your usage.
- We could make our price discount if you place a substantial order with us.
Our Advantages
- Your inquiry related to our products or prices will be replied in 24 hours.
- We have our own research and development team, laboratory, pilot workshop and production plant.
- Factory production has the most stable and the best production processes, to ensure that you are given the best prices and the highest quality products.
- Not only do we provide our customers with products, but we also provide them with free product usage methods and subsequent technical guidance
- Protection of your sales area, ideas of design and all your private information.
- Best quality and competitive price.
Frequently Asked Question
• Q1: Can I get some samples?
A: Yes, we can supply the free sample, but the shipping cost be paid by customers.
• Q2: How to start orders or make payments?
A : PI will be sent first after confirmation of order,enclosed our bank information.Payment by T/T, Western Union LC,Moneygram or Paypal.
• Q3: What's your MOQ?
A : Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that
sample charge is 100% paid.
• Q4: How about delivery leadtime?
A : Delivery lead time: About 3-5 days after payment confirmed.(Chinese holiday not
included)
• Q5: Is there a discount?
A : Different quantity has different discount.
• Q6: How to contact us ?
A : You can chat with us by Trademanager,MSN&Skype Online. You can choose your interested products and send inquiry to us. You can dial our telephone directly, you will get our reply. Send Email to us.
• Q7: How to confirm the Product Quality before placing orders?
A : You can get free samples for some products,you only need to pay the shipping cost or
arrange a courier to us and take the samples. You can send us your product specifications
and requests,we will manufacture the products according to your requests.
Our R&D laboratory Our Factory
Detecting chamber
Quality
We strictly emphasize that products we provide will satisfy or exceed the quality standard of customer.This is to guarantee deliveries of safe and high quality products with reliable services.
We promote the philosophy of treating everyone with objectivity and respect.We will honor our commitments with our customers,suppliers,and respect.We through unbiased pricing,products,and honesty.
Factories and workshops
We is located in wuhan, the central city of China, the core of the Changjiang river economic belt and known as the "thoroughfare of nine provinces".Mainly engaged in Pharmaceuticals Raw Material, Pesticides Raw Materials, API Raw Material, OLED Intermediates, UV Absorber Additive, Chemical Food Additives, Plant Extract Powder, Chinese Herbal Medicine, Polyimide Monomer, Impurity Reference Standards research and development, production, sales and operation or agency of various products and technology import and export business.
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